Sang-Hyun Park, PhD

Professor
Director, Biomaterials Laboratory
The J. Vernon Luck, Sr, MD Orthopaedic Research Center

Dr. Park is the Director of the Biomaterials Laboratory of the JVL Orthopaedic Research Center located at the Orthopaedic Institute for Children in downtown LA. Dr. Park’s education focused in large part on implant biomaterials and degradation. In the last decade, Dr. Park has conducted extensive studies of metal-on-metal joint replacements, including comprehensive analysis of implant failure, and mechanical, biological, and corrosion analysis. These studies include detailed characterization of implant surface and structural damage to determine mechanisms of wear and failure in total hip and knee replacement components, as well as lumbar and cervical disk replacements. In the past, Dr. Park has also conducted landmark research studies using animal models to enhance methods for treating fractures, focusing on the effects of weight bearing, electrical muscle stimulation, and lavage of an open fracture, and the effect of pneumatic compression on blood flow to the fracture and healing. Dr. Park developed a novel method for creating different types of closed fractures in animals, and evaluated these using micro CT imaging, in vivo blood flow measurement, histology, and biomechanical testing.

Affiliations

Orthopaedic Research Society

Research & Publications (selected articles):

Park, S., Lu, Z., Hastings, R. S., Campbell, P. A., & Ebramzadeh, E. (2018). Five Hundred Fifty-five Retrieved Metal-on-metal Hip Replacements of a Single Design Show a Wide Range of Wear, Surface Features, and Histopathologic Reactions. Clinical Orthopaedics and Related Research,476(2), 261-278.
Park, S. H., Lu, Z., Hastings, R. S., Campbell, P. A., & Ebramzadeh, E. (2018). Reply to the Letter to the Editor: Five Hundred Fifty-five Retrieved Metal-on-metal Hip Replacements of a Single Design Show a Wide Range of Wear, Surface Features, and Histopathologic Reactions. Clinical Orthopaedics and Related Research, 476(11), 2280-2281.
Rajfer, R. A., Kilic, A., Neviaser, A. S., Schulte, L. M., Hlaing, S. M., Landeros, J., . . . Park, S. (2017). Enhancement of fracture healing in the rat, modulated by compounds that stimulate inducible nitric oxide synthase. Bone & Joint Research,6(2), 90-97.
Yuan, N., Park, S., Luck, J. V., & Campbell, P. A. (2017). Revisiting the concept of inflammatory cell-induced corrosion. Journal of Biomedical Materials Research Part B: Applied Biomaterials,106(3), 1148-1155.
Campbell, P., Park, S., Zoller, S., Yousuf, J., & Nelson, S. D. (2017). Solid Corrosion Products in the Periprosthetic Tissues of a Distal Femoral Endoprosthesis Used to Treat Osteosarcoma. Corrosion,73(12), 1530-1537.
McKellop, H. A., Hart, A., Park, S. H., Hothi, H., Campbell, P., & Skinner, J. A. (2014). A lexicon for wear of metal‐on‐metal hip prostheses. Journal of Orthopaedic Research, 32(9), 1221-1233.
Amorosa, L. F., Lee, C. H., Aydemir, A. B., Nizami, S., Hsu, A., Patel, N. R., Park, S.H., & Mao, J. J. (2013). Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study. International Journal of Nanomedicine, 8, 1637.
Virk, M. S., Sugiyama, O., Park, S. H., Gambhir, S. S., Adams, D. J., Drissi, H., & Lieberman, J. R. (2011). “Same day” ex-vivo regional gene therapy: a novel strategy to enhance bone repair. Molecular Therapy, 19(5), 960-968.
Cadet, E. R., Vorys, G. C., Rahman, R. K., Park, S. H., Gardner, T. R., Lee, F. Y., … & Ahmad, C. S. (2010). Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model. Journal of Orthopaedic Research, 28(3), 308-314.
Suratwala, S. J., Cho, S. K., van Raalte, J. J., Park, S. H., Seo, S. W., Chang, S. S., … & Lee, F. Y. I. (2008). Enhancement of periprosthetic bone quality with topical hydroxyapatite-bisphosphonate composite. The Journal of Bone and Joint Surgery. American volume., 90(10), 2189.
Virk, M. S., Conduah, A., Park, S. H., Liu, N., Sugiyama, O., Cuomo, A., … & Lieberman, J. R. (2008). Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model. Bone, 42(5), 921-931.